These include previously identified proto‐oncogene such as ERBB3, ERBB4, RET, SRC and YES1; and pro‐survival genes involved in the PI3K and MAPK signalling such as AKT1, AKT3, GSK3A, GSK3B, PDPK1, SGK3, MAP3K4, MAPK1 (also known as ERK2), MAPK4 (also known as ERK4), MAPK13, MAPK15 and ROCK2. 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40Particularly, knock‐down of PDPK1 induced tumour‐specific cell death in both DU145 and PC3 AR‐negative cells, but not in the AR‐positive LNCaP cells nor in the RWPE‐1 non‐transformed prostate epithelial cells. This evidence concerns the gene MAPK15 and neoplasm.