Luke Luke JJ JJ Ott Ott PA PA PD-1 pathway inhibitors: the next generation of immunotherapy for advanced melanoma PD-1 pathway inhibitors: the next generation of immunotherapy for advanced melanoma Oncotarget Oncotarget 2015 2015 6 6 6 6 3479 3479 3492 3492 10.18632/oncotarget.2980 10.18632/oncotarget.2980 25682878 25682878. The gene discussed is PDCD1; the disease is melanoma.