Topalian Topalian SL SL Hodi Hodi FS FS Brahmer Brahmer JR JR Gettinger Gettinger SN SN Smith Smith DC DC McDermott McDermott DF DF Safety, activity, and immune correlates of anti-PD-1 antibody in cancer Safety, activity, and immune correlates of anti-PD-1 antibody in cancer N Engl J Med N Engl J Med 2012 2012 366 366 26 26 2443 2443 2454 2454 10.1056/NEJMoa1200690 10.1056/NEJMoa1200690 22658127 22658127. This evidence concerns the gene PDCD1 and cancer.