For example, the hypermethylation phenotype (Cluster M1) is observed in tumors with TCA cycle-related genes (hereditary in 100%) and associated with a high risk of metastatic disease whereas tumors with Wnt signaling alterations (CSDE1, MAML3) belong to the hypomethylated M3 cluster (hereditary in 0%) [5, 6]. This evidence concerns the gene CSDE1 and metastatic neoplasm.