The induction of HR and defense by the TNL RPP4, the timely induction of HR upon Pst DC3000 AvrRpt2 infection, and the bacterial growth restriction during Pst DC3000 AvrPphB and Pst DC3000 AvrRpt2 specifically require ADR1s and not NRG1s (Fig 2A, 2B, 2C and 2E). The gene discussed is TRIM67; the disease is infection.