KEGG pathway enrichment analysis revealed that the target genes of upregulated DEmiRNAs were significantly enriched in proteoglycans in cancer, microRNAs in cancer, phosphatidylinositol-3 kinases/Akt (PI3K-Akt) signaling pathway, The forkhead box O (FoxO) signaling pathway, and transcriptional misregulation in cancer, while the target genes of downregulated DEmiRNAs were mostly enriched in transforming growth factor-beta (TGF-beta) signaling pathway, proteoglycans in cancer, dorso-ventral axis formation, hepatitis B, and prolactin signaling pathway (Table 3). The gene discussed is PRL; the disease is Hepatitis.