In addition, the disturbance in PI3K-Akt and FoxO signaling pathway has been highly noted in CRC.[44,45] Several studies show miRNAs including miR-125a,miR-135b,miR-182, miR-10b, and miR-21 affected colorectal cancer cell proliferation, migration, invasion, and pathological angiogenesis via PI3K-Akt pathway.[46–49] Interestingly, this study also indicated miR-10b and miR-21 involved in colorectal cancer progress via the PI3K-Akt pathway. This evidence concerns the gene AKT1 and colorectal carcinoma.