This can lead to the release of interleukin-6, endotoxin, vascular endothelial growth factor, and other pro-inflammatory cytokines and growth factors, which seems to promote the growth of residual cancer cells, thereby reducing the long-term survival rate of patients.[47–49] Moreover, abdominal inflammation can directly promote the adhesion, migration, and invasion of cancer cells.[50,51] And rectal leaks are often confined to the pelvis, which increases this chance. This evidence concerns the gene VEGFA and cancer.