Mutational activation of USP8 underlies pathogenesis of pituitary adenoma/Cushing’s Disease and leukemia (Janssen et al., 1998; Ma et al., 2015; Reincke et al., 2015), and USP8 expression correlates with poorer prognosis of lung and other cancers (Kim et al., 2017; Yan et al., 2018). The gene discussed is USP8; the disease is leukemia.