AKR1B10P1 promotes tumour growth both in vitro and in vivo, and clearly facilitates EMT and tumour motility through stabilizing the EMT inducer SOX4 via the sponge‐like interaction with miR‐138, while intensive understanding of the effects on EMT process involve in AKR1B10P1 remains further investigation. The gene discussed is SOX4; the disease is neoplasm.