However, the activation of AKR1B10P1 transcription in HCC tissues inclined to associate with larger HCC tumour size (P < 0.05), more frequency of advanced TNM stages (P < 0.05), higher serum Alpha‐fetoprotein (AFP) quantity (P < 0.01), incidence of tumour microsatellite formation (P < 0.01) and liver cirrhosis (P < 0.05). Here, AFP is linked to hepatocellular carcinoma.