According to the analysis through the Oncomine database (https://www.oncomine.org), SOX4 shows a significant overexpression in 107 out of 464 unique studies covering more than 20 solid tumours, including HCC, and is functionally involved in the activation of multiple signalling pathways regulating tumorigenesis and metastasis, such as PI3K, Wnt, and TGF‐β pathways.41, 42. Here, TGFB1 is linked to hepatocellular carcinoma.