There was no difference between the primary tumor burden within the injected tibiae of mice inoculated with SAMSN1‐KD cells compared to mice inoculated with the EV control cells for either the RPMI‐8226 or JJN3 HMCLs (p > 0.05, Mann–Whitney U test; Figure 5A). Here, SAMSN1 is linked to neoplasm.