Hence, the previously observed ability of Samsn1 to inhibit the outgrowth of disseminated 5TGM1 cells in immunocompetent KaLwRij mice (Figure 2, and Noll, et al.37)was lost in immunodeficient NSG mice, suggesting that the tumor suppressor effect of Samsn1 in MM PCs is dependent on the presence of a functional immune system. This evidence concerns the gene SAMSN1 and Miyoshi myopathy.