However, a comprehensive assessment of the biological effects of modulating SAMSN1 expression in 5 MM cell lines across 4 strains of mice have led to a reassessment of the potency of its tumor suppressor activity, and we now believe that loss of its expression is only likely to play a major role in MM pathogenesis in combination with other dysregulated/mutated genes. Here, SAMSN1 is linked to neoplasm.