SAMSN1 overexpression in HMCLs did not significantly inhibit metastasis following intratibial (i.t.)injection of tumor cells in vivo, which contrasted with the significant suppression of metastasis caused by Samsn1 re‐expression in the 5TGM1/KaLwRij i.t. model of MM. Here, SAMSN1 is linked to Miyoshi myopathy.