ERBB2 and esophageal cancer: After the exclusion of patients with gastric, GEJ, or esophageal cancers, patients receiving HER2-targeted therapy had a longer median OS than patients who did not receive such therapy (18.6 and 10.9 months, respectively; hazard ratio, 0.60; 95% CI, 0.34 to 1.06; P = .07; Fig 3).