The roles of MMP-8 and IGFBP-1 as metabolic regulators in pregnancy are less well known, but an inverse association has been observed between serum IGFBP-1 concentrations and the maternal body weight or BMI [12, 13, 14]; there are also reports of an inverse correlation between serum levels of IGFBP-1 and insulin or insulin resistance both in normal weight [15] and in obese [16] pregnant women. The gene discussed is IGFBP1; the disease is Insulin resistance.