To enhance cancer cell selectivity, we generated a bifunctional melittin peptide by engineering an N-terminal alpha-helical RGD peptide motif (RGD1-melittin, derived from TGF-β3, sequence HGRGDLGRLKK), which interacts with αvβ6 and αvβ3 integrins overexpressed on breast cancer cell membranes and tumor-associated vasculature44–46. Here, TGFB3 is linked to breast carcinoma.