DIS3 and Miyoshi myopathy: By combining the data from the 30 patients with an additional 804 patients from the MMRF CoMMpass trial[43], Maura et al.[42] were similarly able to detect important driver somatic mutations in MM, including well-known driver genes such as KRAS, NRAS, and DIS3, as well as novel putative driver mutations in genes encoding histone linkers (HIST1H1B, HIST1H1D, HIST1H1E, and HIST1H2BK), and mutations in or near genes involved in nucleosome binding.