Approximately 35%−40% of MM patients have IgH translocations (Chr 14), juxtaposed to an assortment of partners [MMSET (NSD2), FGFR2, MAF, CD-1 and D3 on other chromosomes (4, 6, 8, 11, 16 and 20)][44,45]. Here, NSD2 is linked to Miyoshi myopathy.