In early molecular classification schemes of multiple myeloma patients based on heirachical clustering of gene expression in myeloma samples, seven clusters were identifed as proliferation (PR), low bone, multiple myeloma SET domain (MMSET), hyperdiploid, cyclin D1 (CD-1), cyclin D2 (CD-2) and avian musculoaponeurotic fibrosarcoma (MAF)[21]. This evidence concerns the gene CD2 and AL amyloidosis.