In this regard, experiments profiling the effects of LIN28B on the metabolic phenotype of neuroblastoma cells in differing phases of the metastatic process (i.e. growing as tumorspheres, during invasion/migration, initial outgrowth in metastatic lesion), would likely provide insights into not only LIN28 biology, but also further our understanding of neuroblastoma metastasis itself. Here, LIN28B is linked to neuroblastoma.