TGFB2 and colorectal cancer: TGF-β2 drives also EndMT through a Smad-dependent activation of the myocardin-related transcription factor-A (MRTF-A), in pancreatic MS-1 ECs (Mihira et al., 2012) while in an invasive colorectal cancer microenvironment, TGF-β2-induced EndMT involves MRTF-A and B transcription factors through Smad-independent RhoA pathway (Ciszewski et al., 2017).