HGF and myocardial infarction: Another study transfected MSCs with molecularly organic-inorganic hybrid hollow mesoporous organosilica NPs with surface conjugated polyethyleneimine loaded with the hepatocyte growth factor gene and found that the paracrine activity of the hepatocyte growth factor-transfected MSCs was enhanced, which reduced the myocardial cell apoptosis and promoted angiogenesis in the rat model of MI (Zhu et al., 2016).