Although the S1P concentration in plasma and its subsequent effect on malaria could possibly be due to genetic variation, there is lack of information on mutations in genes affecting S1P synthesis (Sphk1, Sphk2), degradation (Spl, Spp1, Spp2) and signaling receptors (S1pr1−3) leading to plasma level of S1P concentration and clinical outcome in malaria. The gene discussed is SPP2; the disease is malaria.