Anticipating implication of circulating S1PR3 as a potential biomarker of severity in malaria induced ARDS, when the expression of the Sphk1 and S1PR3 proteins were investigated in malaria-associated ALI/ARDS, up-regulated expression of these were demonstrated in the lung tissues of experimental mice and human malaria patients (Punsawad and Viriyavejakul, 2019; Viriyavejakul and Punsawad, 2020). The gene discussed is SPHK1; the disease is acute respiratory distress syndrome.