Further, the involvement of S1P receptors, specifically increased S1PR3 concentration with mortality has been documented in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) patients (Sun et al., 2012), yet another severe complication of falciparum malaria which ranges from 5 to 25% of adults and 29% of pregnant women (Taylor et al., 2012). Here, S1PR3 is linked to acute respiratory distress syndrome.