As U87MG/HCC827 and H1975/PC9 differ in relative contribution from mTORC1 versus mTORC2 in promoting TF expression (Figures 2D–F), we considered the possibility that mTORC2 may mediate TF protein stability in the mTORC2-dominant tumor cells like H1975 and PC9. The gene discussed is TF; the disease is neoplasm.