We recently demonstrated that in EGFR-mut and EGFR-TKI resistant NSCLC preclinical models, mTORC2 is critically required for epithelial-mesenchymal transition (EMT) and tumor growth in the mouse brain in a brain-borne microglia/macrophage-dependent manner (10). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.