Particularly, most of these genes (five out of eight) had the same effects on patient survival in head and neck squamous cell carcinoma (HNSC), and the low expression of ZNF718 (p = 0.0027), CCDC7 (p = 0.01), ZNF141 (p = 0.012), ZNF721 (p = 0.029), and ZNF732 (p = 0.045) all demonstrated significant associations with the shorter survival of patients. This evidence concerns the gene ZNF721 and head and neck squamous cell carcinoma.