The CNL of 4p16.3 covers MiR-571, ABCA11P, ZNF141, ZNF595, ZNF718, ZNF721, ZNF732, and ZNF876P. A recent study identified miR-571 as the first miRNA that prevents aberrant DNA replication, and the Cdk2-c-Myc-miR-571 axis was identified as a new pathway for regulating DNA replication, cell cycle, and genomic stability in cancer cells (42). The gene discussed is ZNF718; the disease is cancer.