WNT7A and ulcerative colitis: A significant increase of Wnt7a expression was detected in ulcerative colitis specimens and CRC cells, implying a potential carcinogenic effect (49, 55), whereas Becer et al. found that Colchicum pusillum exerted anticancer activities through activating the Wnt7a/β-catenin pathway, and another study also proved that the loss of Wnt7a expression contributed to tumor progression and predicted a poor prognosis of CRC, which indicates a protective role of Wnt7a during CRC carcinogenesis (56, 111).