A genome-scale analysis has identified that more than 90% of CRC patients carried mutations of one or more downstream components of the Wnt signaling pathway, especially the loss-of-function mutations of adenomatous polyposis coli (APC) and the activating mutations of β-catenin or the extreme overexpression of some members such as frizzled (Fzd) receptors (6). This evidence concerns the gene APC and colorectal carcinoma.