RNF43 and colorectal carcinoma: Additionally, the loss-of-function mutations of E3 ubiquitin ligases ring-finger protein 43 (RNF43), which lead to the excessive activation of Wnt signaling by blocking the ubiquitin-mediated degradation of Fzd receptors and LRP5/6 coreceptors, are dependent on Wnt secretion and frequently detected in CRC cases (8).