At present, there is no report about the role of Wnt8a in cancer; only one study indirectly demonstrated that clofibrate could abrogate the binding of nuclear factor-κB to the Wnt8a promoter and downregulate the expression of Wnt8a and Wnt/β-catenin signaling activity, which ultimately sensitized pancreatic cancer cells to radiation (116). This evidence concerns the gene WNT8A and familial pancreatic carcinoma.