Upregulation of Wnt16 induced by estrogen and progesterone treatment in uterine leiomyoma stem cells could promote the growth of uterine leiomyomas through activating the canonical Wnt pathway in a paracrine manner (138), and the enhanced β-catenin activities initiated by Wnt16 in prostate cancer cells could promote the malignant phenotypes and chemoresistance through preventing cell death (139). Here, WNT16 is linked to prostate cancer.