Until recently, Bauer et al. found two isoforms of Wnt5a protein with opposite functions in cancers (105), and a subsequent study proved that the simultaneous reactivation of the downregulated Wnt5a-long mRNA isoform and knockdown of the upregulated Wnt5a-short mRNA isoform could induce the apoptosis of CRC cells by silencing the expression of β-catenin, providing a reasonable explanation for the obscure role of Wnt5a in CRC previously (106). The gene discussed is WNT5A; the disease is colorectal carcinoma.