ESR1 and colorectal carcinoma: However, the role of Wnt2b in CRC development has been rarely reported; only a recent study demonstrated that Wnt2b was significantly increased in colon cancer cells compared with normal colon epithelial cells, and inhibiting the activity of a CRC-promoting nuclear factor, estrogen receptor, could significantly decrease the Wnt2b/β-catenin signaling in colon cells (34).