Meanwhile, promoter methylation of Wnt5a was strongly associated with the microsatellite instability status of patients with CRC, and multiple histone modifications of Wnt5a were involved in Wnt5a silencing and might promote colon cancer metastasis, providing evidence that epigenetic events may promote Wnt5a-mediated signaling in CRC (102, 103). Here, WNT5A is linked to malignant colon neoplasm.