WNT16 and medical procedure: However, there is still no direct evidence about the role of Wnt16 in colorectal carcinogenesis, except that a study indirectly reported that an ellagic acid derivative performed an antitumor action in CRC cells by downregulating the expression of Wnt16 in a dose-dependent manner (66), indicating a potential carcinogenic role of Wnt16 during tumorigenesis.