Several studies proved that Wnt5a was silenced in most CRC cell lines and specimens due to frequent methylation in its promoter region (41, 42), and Wnt5a acts as a tumor suppressor in human CRC by interfering with the canonical β-catenin signaling but activating the non-canonical signaling pathways (43, 44). The gene discussed is WNT5A; the disease is neoplasm.