Vinculin (VCL), an actin filament (F-actin)-binding protein, may play important roles in cell matrix adhesion, cell–cell adhesion, cell morphology, and locomotion (51, 52), indicating that TIIC polarity and synaptic compositions are modulated, which may affect TCR signal transduction and functional output in the TIICs of PCa microenvironment. This evidence concerns the gene VCL and posterior cortical atrophy.