For the diagnosis of AFP-negative small HCC (n = 27), CCT3 exhibited an AUROC of 0.84, sensitivity of 88.9%, and specificity of 70.5%, and IQGAP3 exhibited an AUROC of 0.822, sensitivity of 85.2%, and specificity of 71.6%) (106). Here, IQGAP3 is linked to hepatocellular carcinoma.