AFP and chronic hepatitis: Huang et al. (171) also found that the combination of fibrinogen to pre-albumin ratio and gamma-glutamyl transpeptidase to platelet ratio had a good ability to detect ANHC from the control group (AUROC = 0.977), AFP-negative chronic hepatitis (AUC = 0.745), and AFP-negative LC (AUC = 0.666) and possessed a larger area (0.943, 0.971) than fibrinogen to pre-albumin ratio and gamma-glutamyl transpeptidase to platelet ratio alone for differentiating small or early ANHC.