Aldo-keto reductase family 1 member B10 (AKR1B10) is a novel secretory protein that is overexpressed in multiple tumors, including lung cancer, breast cancer, and colorectal cancer (68, 69), and is a potential diagnostic and prognostic biomarker for HCC (70–73). Here, AKR1B10 is linked to hepatocellular carcinoma.