Serum hs-CRP had a better performance than AFP (AUROC 0.903 vs. 0.824, sensitivity 84.2 vs. 74.4%, specificity 61.6 vs. 55.6%) for diagnosing HCC, and the diagnostic performance improved when the two indicators were combined (AUROC = 0.998, sensitivity = 94.1%), with similar positive rates between APHC and ANHC patients (86.9 vs. 84.6%) (126), indicating that serum hs-CRP level may be a useful diagnostic biomarker complementary to AFP for ANHC diagnosis. Here, AFP is linked to hepatocellular carcinoma.