AFP and cirrhosis of liver: Liu et al. (151) found that the serum levels of GS in HCC patients were higher compared with liver cirrhosis patients and healthy controls, and the AUROCs of GS and AFP for HCC diagnosis were 0.848 and 0.861, respectively, while the AUROC was 0.913 (sensitivity 81.9%, specificity 100%) for differentiating ANHC from healthy control, and the sensitivity and specificity achieved to 82.5 and 93% when combining GS with AFP.