AFP and hepatocellular carcinoma: Best et al. (174) established a diagnostic algorithm based on age, sex, and tumor biomarkers of AFP, AFP-L3, and DCP for the diagnosis of HCC, and the model showed a sensitivity of 67.5% and specificity over 90% for diagnosing ANHC and an AUROC of 0.924, specificity of 93.3%, and sensitivity of 85.6% for diagnosing early-stage HCC.