AFP and hepatocellular carcinoma: Ma et al. (126) used a high-sensitivity CRP (hs-CRP) assay, which could be quantified as low as 0.04 mg/L of CRP and found that serum hs-CRP levels were significantly elevated in the HCC group compared with those in the non-HCC group and did not correlate with tumor Edmondson grade, TNM stage, or AFP status.