Plasma MCM6 mRNA and protein levels were significantly upregulated in HCC and correlated with vascular invasion, tumor progression, and lymph node metastasis but not with AFP levels or clinical features (age, gender, tumor size, HBV or HCV infection status, or Child–Pugh score) (121), with a sensitivity of 67.2% and a specificity of 89.8% for MCM6 protein to discriminating HCC from non-HCC. The gene discussed is AFP; the disease is hepatocellular carcinoma.