Plasma CCT3 and IQGAP3 were both valuable for differentiating ANHC (n = 38) from LC (n = 88) (CCT3 with an AUROC of 0.871, sensitivity of 92.1%, and specificity of 70.5% and IQGAP3 with an AUROC of 0.804, sensitivity of 81.6%, and specificity of 71.6%) and differentiating small HCC (n = 47) from LC (CCT3 with an AUROC of 0.761, sensitivity of 76.6%, and specificity of 70.5% and IQGAP3 with an AUROC of 0.753, sensitivity of 74.5%, and specificity of 71.6%), which were better than that of AFP (AUROC 0.707, sensitivity 53.2%, and specificity 68.2%) (106). This evidence concerns the gene AFP and hepatocellular carcinoma.