ANGPTL2 also showed good performance for the differentiation of HCC from chronic liver diseases, with an AUROC of 0.831, sensitivity of 68.3%, specificity of 87.3%, and accuracy of 80.4%, which was also better than that of AFP (AUROC 0.777, sensitivity 42.9%, specificity 93.3%, and accuracy 79.2%), for the diagnosis of ANHC, with an AUROC of 0.919 for differentiating ANHC from healthy controls and an AUROC of 0.798 (95% CI 0.710–0.886) for differentiating ANHC from high-risk controls. Here, AFP is linked to hepatocellular carcinoma.