AFP and hepatocellular carcinoma: Interestingly, AFP was positive in 97 of 164 (59.1%) HCCR-1-negative HCC patients, and the positive rate was up to 77.2% in combination of both AFP and HCCR-1, indicating that HCCR-1 expression is not associated with AFP levels in many HCC cases and thus HCCR-1 can complementary to AFP for ANHC diagnosis.