Serum CYP17A1 exhibited better diagnostic performance than did AFP in differentiating HCC vs. healthy controls, with an AUROC of 0.91, sensitivity of 86.9%, and specificity of 76.8% for CYP17A1 and an AUROC of 0.78, sensitivity of 65.6%, and specificity of 65.6% for AFP (149). Here, AFP is linked to hepatocellular carcinoma.