The authors found that the miRNA classifier had an AUROC of 0.825 for detecting ANHC, with sensitivities of 78.8, 75.8, and 80.0% and specificities of 86.3, 88.2, and 91.1% in the training cohort, validation cohort 1, and validation cohort 2, respectively, and had an AUROC of 0.812 to identify ANHC from at-risk controls, and this classifier also had larger AUROCs than did AFP to detect small-size (AUROC 0.833 vs. 0.727) and early-stage (AUROC 0.824 vs. 0.754) HCC. Here, AFP is linked to hepatocellular carcinoma.