AFP and hepatocellular carcinoma: et al. (91) found that serum levels of ANGPTL2 is gradually elevated with the liver injury progression and reached a peak in HCC patients with chronic HBV infection, with better diagnostic performance (AUROC 0.952, sensitivity 95.2%, specificity 81.8%, and accuracy 90.7%) than AFP (AUROC 0.824, sensitivity 71.4%, specificity 95.5%, and accuracy 81.5%) for the differentiation of HCC from healthy controls.