CAP2 expression in HCC correlated with tumor size, histological grade, and clinical stage, but not with plasma AFP level, HBV infection status, and patient's gender and ag, (99), and higher levels of CAP2 were found in HCC compared with cirrhosis patients, with better performance than AFP for diagnosing general HCC (AUROC 0.86 vs. 0.75, sensitivity 82.6 vs. 59.3%, specificity 79.3 vs. 83.1%) and for diagnosing early-stage HCC patients (AUROC 0.81 vs. 0.67, sensitivity 78.6 vs. 40.4%, specificity 81.4 vs. 83.1%). This evidence concerns the gene AFP and Cirrhosis.