Patients with AF had higher concentration of highly sensitive C-reactive protein (MD: 5.5 mg/dL; 95% CI: 1.2–9.8; I2: 90.0%) (Figure 3), of N-terminal pro b-type natriuretic peptide (MD: 45.0 pg/mL; 95% CI: 28.8–61.2) (Supplementary Figure 6) and of interleukin-6 (p = 0.05) [94] than those without AF. This evidence concerns the gene CRP and atrial fibrillation.