That lymphocytes may not be needed for the effects of eosinophils on cancer growth has been previously reported in different models of heterotopically engrafted solid tumors,51 as well as in colitis-associated CRC models and Apcmin/+ mice, which develop intestinal tumors spontaneously.7 In our AOM+DSS-induced CRC model we detected IL-33-induced TATE, which was accompanied by reduced tumor growth, but we failed to see changes in the other leukocytes measured. Here, IL33 is linked to infectious otitis media.