Furthermore, we detected reduced infiltration of monocytes in ∆dblGATA-1 mice post IL-33 treatment which has been previously shown in wild type mice with melanoma.25 Considering the minor changes in the tumor microenvironment after IL-33 treatment, our data rather suggested a direct anti-tumorigenic effect of eosinophils on tumor cells. The gene discussed is IL33; the disease is neoplasm.