TGFB1 and neoplasm: In Ewing’s sarcoma (ES), elevated expression of miR-20b was shown to directly target TGFβ receptor II (TGFBR2) leading to elevated MYC expression, hence inhibition of miR-20b reduced ES cell grow, cell cycle progression, and in vivo tumor formation, thus corroborating the important role of loss of TGFβ signaling in promoting ES tumor formation32.