In Ewing’s sarcoma (ES), elevated expression of miR-20b was shown to directly target TGFβ receptor II (TGFBR2) leading to elevated MYC expression, hence inhibition of miR-20b reduced ES cell grow, cell cycle progression, and in vivo tumor formation, thus corroborating the important role of loss of TGFβ signaling in promoting ES tumor formation32. The gene discussed is TGFB1; the disease is Ewing sarcoma.