VEGFA and aneurysm: Previous studies proposed that elevations of vascular endothelial growth factor (VEGF) or alterations in the vascular wall [10] and many hemodynamic changes, such as flow-related aneurysms [11], abnormally high blood flow through shunting [12], smaller bAVMs, a single and/or stenosed draining vein, and so on [13], may contribute to bAVMs rupture.