SCARB1 and obesity due to melanocortin 4 receptor deficiency: This article will review studies that have explored Scavenger Receptor Class B type 1 (SR-B1)’s role in well-known risk factors for stroke, such as smoking, diabetes mellitus, diet, physical inactivity, obesity, hypercholesterolemia, atherosclerosis, coronary heart disease, hypertension, and sickle cell disease.