EGFR and adenocarcinoma: Otherwise, patients with mutation at exon 19/21/and dual mutation (EGFR-sensitive mutations) (p = 0.018), adenocarcinoma histology (p = 0.02), advanced stage (p = 0.002), advanced T status (p = 0.009) and advanced N status (p < 0.001) at diagnosis had a significantly shorter mBMFS than their counterparts.