Additionally, IL-37 reduces inflammation and suppresses immune responses [43] both in epidermal keratinization and cancer; hence, exploring the role of the novel IL-37 isoform (similar to IL-37β, sharing exons 1, 2, 4, 5, and 6) with less stability than reference transcript identified in our study in highly keratinized OSCC will be of interest. The gene discussed is IL37; the disease is cancer.