However, the upregulation of PRMT1 and EEF1D in MD/PD/WD metastatic OSCC compared to WD OSCC suggests that PRMT1-dependent-C/EBPα-methylation/cyclin D1 expression and Akt-mTOR/Akt-bad signaling mediated enhanced cell proliferation, respectively [17, 18]. Here, AKT1 is linked to Menkes disease.