Two additional hallmarks of cancer metabolic reprogramming, ALDOA, and PGK1, were upregulated in keratinized OSCC, as indicated by increased glycolysis and metabolic reprogramming, which creates oncogenic stress [22, 23], as suggested in other solid tumors, such as non-small cell lung cancer (NSCLC) [24]. The gene discussed is ALDOA; the disease is non-small cell lung carcinoma.