Based on unsupervised clustering, 34 transcripts (with isoforms of TPI1 and TECR) and 5 housekeeping genes were distributed among keratinized OSCCs at different levels of differentiation, i.e., K2-K4, including 15 WD FFPE (K4), 16 WD (K4), 5 MD (K3), 1 PD (K2), and 8 WD (K4) samples with unilateral/bilateral lymphadenopathy with metastatic features. The gene discussed is TPI1; the disease is Lymphadenopathy.