By aggregate analysis of pooled oral cancer samples, we identified a significant copy number gain of Ch7p11.2 (EGFR-100% CNV overlap and 81.81% frequency) and copy number loss of Ch3p21.1 (PBRM1-25.46% CNV overlap and 54.54% frequency), Ch3p14.2 (FHIT-0.32% CNV overlap and 54.54% frequency), Ch19p13.3 (STK11-100% CNV overlap and 45.45% frequency) and Ch16 p13.3 (TSC2-79.73% CNV overlap and 45.45% frequency). The gene discussed is FHIT; the disease is lip and oral cavity carcinoma.