Although several related studies focusing on DUXAP8 in HCC were previously reported 63-65, our study has several main findings that could distinguished from them, such as in both diagnostic and prognostic significance of DUXAP8 and it-related PCGs, construction of risk score model and nomogram, potential target drugs toward DXUAP8 aspects. This evidence concerns the gene DUXAP8 and hepatocellular carcinoma.