In our study, we identified 11 DRGs (ACTR8, DMC1, MAGEF1, MC1R, POLG, RBM17, SFPQ, TERF2IP, TP53BP1, UIMC1, USP7), whose altered expression level was closely related to the prognosis of colon cancer patients. This evidence concerns the gene SFPQ and malignant colon neoplasm.