In our study, we identified 11 DRGs (ACTR8, DMC1, MAGEF1, MC1R, POLG, RBM17, SFPQ, TERF2IP, TP53BP1, UIMC1, USP7), whose altered expression level was closely related to the prognosis of colon cancer patients. The gene discussed is USP7; the disease is malignant colon neoplasm.