In our study, we identified 11 DRGs (ACTR8, DMC1, MAGEF1, MC1R, POLG, RBM17, SFPQ, TERF2IP, TP53BP1, UIMC1, USP7), whose altered expression level was closely related to the prognosis of colon cancer patients. Here, POLG is linked to malignant colon neoplasm.