Anti-PD-L1 antibodies including atezolizumab (MPDL3280A), durvalumab (MEDI4736), avelumab, and pembrolizumab have been approved by Food and Drug Administration for the treatment of melanoma, Hodgkin's lymphoma, urothelial carcinoma, metastatic head and neck squamous cell carcinoma, and lung cancer [6–9]. This evidence concerns the gene CD274 and lung carcinoma.