MAPK14 and rheumatoid arthritis: Moreover, Several novel structures of imidazole analogues such as phenoxypyrimidine (9), pyridinylimidazoles (10, 11), pyrazolo (12), and pyridines (1) have shown clinical importance through exhibition of p38 inhibitor activity (13), among them some members of the pyridinyl-imidazole class have advanced into clinical trials as probable therapies for the treatment of RA.