CNR2 and asthma: In order to better understand the role of the CB2 receptor in the OVA-induced asthma model, a combination of both selective CB2 agonist (AM1241, (R, S) -3- (2-Iodo-5-nitrobenzoyl) -1- (1-methyl-2-piperidinylmethyl) -1) and antagonist (AM630, 6-Iodo-2-methyl-1- [2- (4-morpholinyl) ethyl] -1H-indol-3-yl] (4-methoxyphenyl) methanone, Iodopravadoline) was used to improve inflammatory hypersensitivity and edema in rats (21).