By comparing the ATM-MT group immune-related gene and immune cell-related gene expression with that of the ATM-WT group, we found that ATM-MT bladder cancer cells might promote the infiltration of cytotoxic cells and Th17 cells into tumor tissues by secreting increased amounts of the chemokine CCL5 and activating dendritic cells to enhance ICI therapy. Here, CCL5 is linked to urinary bladder cancer.