FH involves mutations in the gene encoding LDL receptor (LDLR; 90% of reported FH–causing variants), gene encoding apo-lipoprotein B (APOB; 5–10%), and, rarely, gene encoding protein convertase subtilisin/kexin type 9 (PCSK9; 1%) (Sturm et al., 2018). The gene discussed is APOB; the disease is familial hyperaldosteronism.