Furthermore, the downstream regulation mechanisms of ECRG4 in cancers, particularly BCa, remain unclear, although Huang et al. (2019) have demonstrated that ECRG4 inhibits the migration and proliferation of oral squamous cell carcinoma via a non-coding RNA-related mechanism by repressing the BC200 lncRNA/MMPs axis. This evidence concerns the gene ECRG4 and oral cavity squamous cell carcinoma.