Eeckhoute et al. (2006) illustrated that NFIC induction could directly repress CCND1 transcription by dissociating estradiol stimulation in breast cancer. However, Lee et al. (2015) showed that NFIC could directly bind to the promoter region of KLF4 and increase its transcriptional activity in breast cancer. The gene discussed is CCND1; the disease is breast carcinoma.