Although many studies have strongly suggested the role of ECRG4 as a potential tumor suppressor gene, some other reports have also demonstrated the oncogenic role of ECRG4 in patients with papillary thyroid carcinoma (Chen J. et al., 2015) and hepatocellular carcinoma (Ge et al., 2017). This evidence concerns the gene ECRG4 and thyroid gland papillary carcinoma.