IFN-γ might also play a role in the development of skin inflammation in aged CD4CreTTPf/f mice, as the levels of IFN-γ were also increased in the TH0 and TH17 cells lacking TTP (Figure 3A), which is consistent with a previous report that TTP promotes IFN-γ mRNA degradation (35). Here, IFNG is linked to dermatitis.