Later, Claudia Mauri et al. used agonistic anti-CD40 and collagen to stimulate arthritic B cells, increasing the secretion of IL-10 in B cell subsets to control the proinflammatory Th1 type response while reducing secretion of interferon (IFN)-γ; the findings proved that these B cells play important roles in immune regulation in arthritis models (33). This evidence concerns the gene IL10 and Arthritis.