Importantly, depletion of F4/80+CD11b+ macrophages after the injection of S. mansoni eggs reduced the size of granulomas, downregulated the expression of IL-13ra2 (IL-13Rα2), Retnla and Chi3l3 and affected CD4+ Th2 cell responses in the lung (Borthwick et al., 2016). The gene discussed is IL13RA2; the disease is Granuloma.