GSDMD and infection: To confirm the roles of Caspase-1/11 and Gsdmd in the pathogenicity of SS2-induced STSS in vivo, we infected IP WT, Caspase-1/11−/−, and Gsdmd−/− mice with a higher dose of 2 × 109 CFU SS2 and observed their activity and survival every 2 h until 24 h post infection.