FIS1 and type 2 diabetes mellitus: However, the protein expression of MFN2 (2.61-fold, p < 0.01) (Figures 8B,D), DRP1 (2.1-fold, p < 0.01) (Figures 8B,E) and FIS1 (3.29-fold, p < 0.01) (Figures 8B,F) was dramatically increased in the T2DM-HIIT group.