In addition, ATF3 upregulates the expression of some genes involved in tumor metastasis, including FN-1, Twist-related protein 1 (TWIST1), plasminogen activator inhibitor-1, urokinase-type plasminogen activator, caveolin-1, and Slug, in MCF10CA1a cells (70). The gene discussed is TWIST1; the disease is neoplasm.