Although in our study we found no significant differences in IGF-1 levels between women and men in both MDD and HC groups, several previous studies have shown variability across the genders in IGF-1 levels in MDD patients (67–69) These differences between genders may be explained by variations of sex hormone or fluctuations of growth hormone and IGF-1-binding protein (67). Here, IGFBP1 is linked to major depressive disorder.