Several antidepressants were shown to increase serum/plasma BDNF levels in MDD persons compared to pre-treatment levels, including agomelatine (41), duloxetine (27), escitalopram (27, 43, 44), fluoxetine (41, 45), milnacipran (36), paroxetine (36, 38, 44), sertraline (44), venlafaxine (44), and vortioxetine (17, 46). Here, BDNF is linked to major depressive disorder.