IL-6, IL-8, and GMCSF have not previously been directly linked to the pathogenesis of deranged ion transport in ARDS but there is limited evidence of the effects of IL-6 in reduction of endothelial barrier integrity in vitro and IL-8 in involvement of smoke inhalation induced lung injury in the rabbit model (Laffon et al., 1999; Birukova et al., 2016). The gene discussed is CXCL8; the disease is acute respiratory distress syndrome.