The effects of proteasome inhibition in COVID-19 are not clear; however, the extensive pro-inflammatory response in severe COVID-19 patients (Chen G. et al., 2020; Qin et al., 2020) suggests that drugs targeting NF-κB (Table 3) (Baeuerle and Baichwal, 1997; Miller et al., 2010) could be of benefit in dampening excessive cytokine responses in some COVID-19 patients. Here, NFKB1 is linked to COVID-19.