ZDHHC17 and juvenile Huntington disease: GPM6a is known to be a good endogenous substrate of HIP14/Zdhhc17, a palmitoyl acetyltransferase (protein palmitoyl acyltransferase; PAT) implicated in Huntington disease, a human hereditary neurodegenerative disease (Butland et al., 2014; Figure 2B).