GPM6a is known to be a good endogenous substrate of HIP14/Zdhhc17, a palmitoyl acetyltransferase (protein palmitoyl acyltransferase; PAT) implicated in Huntington disease, a human hereditary neurodegenerative disease (Butland et al., 2014; Figure 2B). The gene discussed is ZDHHC17; the disease is neurodegenerative disease.