The use of Ccr6–/– mice in experimental autoimmune encephalomyelitis (EAE) study, an animal model of brain inflammation for the study of human CNS diseases characterized by mononuclear cell infiltration and demyelination, showed delayed disease onset and more neurological damage and increased mortality compared to wild-type mice (Villares et al., 2009). The gene discussed is CCR6; the disease is experimental autoimmune encephalomyelitis.