INS and type 2 diabetes mellitus: Additionally, the reduction in STARD10 levels, and not the increase in ARAP1 levels, was responsible for the impaired insulin secretion in pancreatic β cells, suggesting that the protective role of the rs1552224C allele in T2DM might be mediated by the overexpression of STARD10 and the subsequent improvement in glucose-induced Ca2+ dynamics and insulin secretion in pancreatic β cells 31.