Our study investigated the influence of the ten SNPs in KCNQ1, ARAP1, and KCNJ11 (rs151290, rs163184, rs2237892, rs2237897, rs2283228 and rs231362 in KCNQ1, rs1552224 in ARAP1, and rs5210 and rs5219 in KCNJ11), which influence insulin secretion by mediating ion dynamics, on T2DM in a Chinese population. This evidence concerns the gene KCNQ1 and type 2 diabetes mellitus.