RRM2 may co-express with RFC44 (correlated with stromal cells and tumor cells) to increase the number of tumor cells and reduce the number of stromal cells, and subsequently regulate the expression of the RPL family (RPL30, RPL23 and RPL3 et al.)or CENPI, KIF2A and CASCS (correlated with lymphocyte infiltration) to promote lymphocyte infiltration. The gene discussed is RPL3; the disease is neoplasm.