After the lymphocyte infiltration, the expression of CNG11 or PGR (correlated with tumor nuclei) would be regulated to enhance the malignant behavior by increasing the number of tumor nuclei, and further regulate the expression of GNA15/LTB4R or SFN/KRT14 (correlated with stromal cells) to reduce the number of stromal cells. Here, LTB4R is linked to neoplasm.