With 192 samples (29 normal, 30 low-grade dysplasia, 30 high-grade dysplasia and 103 invasive cancer tissue specimens) and SiHa cervical cancer cells, Su et al. reported the expression of RRM2 in cancer tissues was increased when compared to high-grade dysplasia, low-grade dysplasia or normal cervical tissues 40. This evidence concerns the gene RRM2 and dysplasia.